| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-U4/U6 small nuclear ribonucleoprotein Prp3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRPF3 |
| Gene ID: | 9129 |
| Uniprot ID: | PRPF3_HUMAN |
| Specificity: | This antibody detects endogenous levels of PRPF3 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human PRPF3 |
| Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination by PRPF19 and deubiquitination by USP4. 'Lys-63'-linked ubiquitination increases the affinity for PRPF8 and may regulate the assembly of the U4/U6-U5 tri-snRNP complex. |
| Function | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). |
| Protein Name | U4/U6 Small Nuclear Ribonucleoprotein Prp3 Pre-Mrna-Splicing Factor 3 Hprp3 U4/U6 Snrnp 90 Kda Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus Nucleus Speckle |
| Alternative Antibody Names | Anti-U4/U6 Small Nuclear Ribonucleoprotein Prp3 antibody Anti-Pre-Mrna-Splicing Factor 3 antibody Anti-Hprp3 antibody Anti-U4/U6 Snrnp 90 Kda Protein antibody Anti-PRPF3 antibody Anti-HPRP3 antibody Anti-PRP3 antibody |
Information sourced from Uniprot.org