| Host: | Mouse |
| Applications: | ELISA |
| Reactivity: | All Species |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Progesterone is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | EBS-O-049 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: | PGRMC2 |
| Gene ID: | 10424 |
| Uniprot ID: | PGRC2_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with Progesterone-11a-hemisuccinate conjugated to BSA (Progesterone-11a-HMS-BSA). Fusion partner: X63-Ag8-653. |
| Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 2 Progesterone Membrane-Binding Protein Steroid Receptor Protein Dg6 |
| Database Links | Reactome: R-HSA-8980692 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013408 Reactome: R-HSA-9013423 Reactome: R-HSA-9707616 |
| Cellular Localisation | Membrane Single-Pass Membrane Protein Nucleus Envelope Endoplasmic Reticulum Secreted |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 2 antibody Anti-Progesterone Membrane-Binding Protein antibody Anti-Steroid Receptor Protein Dg6 antibody Anti-PGRMC2 antibody Anti-DG6 antibody Anti-PMBP antibody |
Information sourced from Uniprot.org