| Function | Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. |
| Protein Name | Protein Arginine N-Methyltransferase 2Histone-Arginine N-Methyltransferase Prmt2 |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmNucleusTranslocates From The Cytoplasm To The NucleusAfter Hormone ExposureExcluded From NucleolusIsoform Prmt2alpha: NucleusIsoform Prmt2beta: CytoplasmNucleolusIsoform Prmt2gamma: NucleusIsoform Prmt2l2: CytoplasmPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 2 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt2 antibodyAnti-PRMT2 antibodyAnti-HMT1 antibodyAnti-HRMT1L1 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HeLa cells using [KO Validated] PRMT2 Rabbit polyclonal antibody (STJ28398). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/101688/389745/STJ28398_1__85710.1713159476.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] PRMT2 Rabbit polyclonal antibody (STJ28398). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution.")
