| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Peroxiredoxin-1 (31-80 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDX1 |
| Gene ID: | 5052 |
| Uniprot ID: | PRDX1_HUMAN |
| Immunogen Region: | 31-80 aa |
| Specificity: | PRX I Polyclonal Antibody detects endogenous levels of PRX I protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human PRDX1 at the amino acid range 31-80 |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. |
| Protein Name | Peroxiredoxin-1 Natural Killer Cell-Enhancing Factor A Nkef-A Proliferation-Associated Gene Protein Pag Thioredoxin Peroxidase 2 Thioredoxin-Dependent Peroxide Reductase 2 Thioredoxin-Dependent Peroxiredoxin 1 |
| Database Links | Reactome: R-HSA-3299685 Reactome: R-HSA-5628897 Reactome: R-HSA-8862803 Reactome: R-HSA-9818027 |
| Cellular Localisation | Cytoplasm Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Peroxiredoxin-1 antibody Anti-Natural Killer Cell-Enhancing Factor A antibody Anti-Nkef-A antibody Anti-Proliferation-Associated Gene Protein antibody Anti-Pag antibody Anti-Thioredoxin Peroxidase 2 antibody Anti-Thioredoxin-Dependent Peroxide Reductase 2 antibody Anti-Thioredoxin-Dependent Peroxiredoxin 1 antibody Anti-PRDX1 antibody Anti-PAGA antibody Anti-PAGB antibody Anti-TDPX2 antibody |
Information sourced from Uniprot.org