| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRDM6 (376-595) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRDM6 |
| Gene ID: |
93166 |
| Uniprot ID: |
PRDM6_HUMAN |
| Immunogen Region: |
376-595 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 376-595 of human PRDM6 (NP_001129711.1). |
| Immunogen Sequence: |
LQCIAQDENLNVPSTVMEAM CRQDALQPFNKSSKLAPTTQ QRSVVFPQTPCSRNFSLLDK SGPIESGFNQINVKNQRVLA SPTSTSQLHSEFSDWHLWKC GQCFKTFTQRILLQMHVCTQ NPDRPYQCGHCSQSFSQPSE LRNHVVTHSSDRPFKCGYCG RAFAGATTLNNHIRTHTGEK PFKCERCERSFTQATQLSRH QRMPNECKPITESPESIEVD |
| Function | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. |
| Protein Name | Putative Histone-Lysine N-Methyltransferase Prdm6Pr Domain Zinc Finger Protein 6Pr Domain-Containing Protein 6 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Putative Histone-Lysine N-Methyltransferase Prdm6 antibodyAnti-Pr Domain Zinc Finger Protein 6 antibodyAnti-Pr Domain-Containing Protein 6 antibodyAnti-PRDM6 antibodyAnti-PFM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
