| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat/Cow/Dog/Zebrafish |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Serine/threonine-protein phosphatase 4 catalytic subunit is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Purification: | Affinity purification |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-1:2000 IHC 1:500-1:1000 IF 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP4C |
| Gene ID: | 5531 |
| Uniprot ID: | PP4C_HUMAN |
| Specificity: | PPX Monoclonal Antibody detects endogenous levels of PPX protein. |
| Immunogen: | Purified recombinant human PPX protein fragments expressed in E.coli. |
| Function | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. |
| Protein Name | Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit Pp4c Pp4 Protein Phosphatase X Pp-X |
| Database Links | Reactome: R-HSA-5693607 |
| Cellular Localisation | Cytoplasm Nucleus Cytoskeleton Microtubule Organizing Center Centrosome |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit antibody Anti-Pp4c antibody Anti-Pp4 antibody Anti-Protein Phosphatase X antibody Anti-Pp-X antibody Anti-PPP4C antibody Anti-PPP4 antibody Anti-PPX antibody |
Information sourced from Uniprot.org