| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP2R2A |
| Gene ID: | 5520 |
| Uniprot ID: | 2ABA_HUMAN |
| Immunogen Region: | 1-447 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-447 of human PP2A-B55 Alpha/PR55 Alpha/PPP2R2A (NP_002708.1). |
| Immunogen Sequence: | MAGAGGGNDIQWCFSQVKGA VDDDVAEADIISTVEFNHSG ELLATGDKGGRVVIFQQEQE NKIQSHSRGEYNVYSTFQSH EPEFDYLKSLEIEEKINKIR WLPQKNAAQFLLSTNDKTIK LWKISERDKRPEGYNLKEED GRYRDPTTVTTLRVPVFRPM DLMVEASPRRIFANAHTYHI NSISINSDYETYLSADDLRI NLWHLEITDRSFNIVDIKPA NMEELTEVITAAEFHPNSC |
| Tissue Specificity | Expressed in all tissues examined. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha IsoformPp2a Subunit B Isoform B55-AlphaPp2a Subunit B Isoform Pr55-AlphaPp2a Subunit B Isoform R2-AlphaPp2a Subunit B Isoform Alpha |
| Database Links | Reactome: R-HSA-2995383Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-975957 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform antibodyAnti-Pp2a Subunit B Isoform B55-Alpha antibodyAnti-Pp2a Subunit B Isoform Pr55-Alpha antibodyAnti-Pp2a Subunit B Isoform R2-Alpha antibodyAnti-Pp2a Subunit B Isoform Alpha antibodyAnti-PPP2R2A antibody |
Information sourced from Uniprot.org