| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP1R14A |
| Gene ID: | 94274 |
| Uniprot ID: | PP14A_HUMAN |
| Immunogen Region: | 1-147 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human PPP1R14A (NP_150281.1). |
| Immunogen Sequence: | MAAQRLGKRVLSKLQSPSRA RGPGGSPGGLQKRHARVTVK YDRRELQRRLDVEKWIDGRL EELYRGMEADMPDEINIDEL LELESEEERSRKIQGLLKSC GKPVEDFIQELLAKLQGLHR QPGLRQPSPSHDGSLSPLQD RARTAHP |
| Tissue Specificity | Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. |
| Function | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 14a17 Kda Pkc-Potentiated Inhibitory Protein Of Pp1Protein Kinase C-Potentiated Inhibitor Protein Of 17 KdaCpi-17 |
| Database Links | Reactome: R-HSA-5625740 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Subunit 14a antibodyAnti-17 Kda Pkc-Potentiated Inhibitory Protein Of Pp1 antibodyAnti-Protein Kinase C-Potentiated Inhibitor Protein Of 17 Kda antibodyAnti-Cpi-17 antibodyAnti-PPP1R14A antibodyAnti-CPI17 antibodyAnti-PPP1INL antibody |
Information sourced from Uniprot.org