| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP1R12B |
| Gene ID: | 4660 |
| Uniprot ID: | MYPT2_HUMAN |
| Immunogen Region: | 660-930 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-930 of human PPP1R12B (NP_002472.2). |
| Immunogen Sequence: | TFSRSRAERQAQEQPREKPT DTEGLEGSPEKHEPSAVPAT EAGEGQQPWGRSLDEEPICH RLRCPAQPDKPTTPASPSTS RPSLYTSSHLLWTNRFSVPD SESSETTTNTTTAKEMDKNE NEEADLDEQSSKRLSIRERR RPKERRRGTGINFWTKDEDE TDGSEEVKETWHERLSRLES GGSNPTTSDSYGDRASARAR REAREARLATLTSRVEEDSN RDYKKLYESALTENQKLKT |
| Tissue Specificity | Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. |
| Function | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 12bMyosin Phosphatase-Targeting Subunit 2Myosin Phosphatase Target Subunit 2 |
| Database Links | Reactome: R-HSA-2565942 O60237-4Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberAlong Actomyosin Filaments |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Subunit 12b antibodyAnti-Myosin Phosphatase-Targeting Subunit 2 antibodyAnti-Myosin Phosphatase Target Subunit 2 antibodyAnti-PPP1R12B antibodyAnti-MYPT2 antibody |
Information sourced from Uniprot.org
