Tissue Specificity | Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung. |
Function | Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. |
Protein Name | Protein-Serine O-Palmitoleoyltransferase PorcupineProtein Mg61 |
Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-5340573 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Protein-Serine O-Palmitoleoyltransferase Porcupine antibodyAnti-Protein Mg61 antibodyAnti-PORCN antibodyAnti-MG61 antibodyAnti-PORC antibodyAnti-PPN antibody |
Information sourced from Uniprot.org