Anti-MRGPRX1 antibody (271-320) (STJ94200)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MRGX1. AA range:271-320
General Information
| Short Description | Rabbit polyclonal anti-Mas-related G-protein coupled receptor member X1 (271-320) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRGPRX1 |
| Gene ID | 259249 |
| Uniprot ID | MRGX1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MRGX1. AA range:271-320 |
| Immunogen Region | 271-320 |
| Specificity | MRGX1 Polyclonal Antibody detects endogenous levels of MRGX1 protein. |
Additional Info
| Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
| Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. |
| Protein Name | Mas-Related G-Protein Coupled Receptor Member X1Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mas-Related G-Protein Coupled Receptor Member X1 antibodyAnti-Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 antibodyAnti-MRGPRX1 antibodyAnti-MRGX1 antibodyAnti-SNSR3 antibodyAnti-SNSR4 antibody |
Information sourced from Uniprot.org