| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POMGNT2 |
| Gene ID: | 84892 |
| Uniprot ID: | PMGT2_HUMAN |
| Immunogen Region: | 160-340 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human POMGNT2 (NP_116195.2). |
| Immunogen Sequence: | NPDNLMHVFHDDLLPLFYTL RQFPGLAHEARLFFMEGWGE GAHFDLYKLLSPKQPLLRAQ LKTLGRLLCFSHAFVGLSKI TTWYQYGFVQPQGPKANILV SGNEIRQFARFMTEKLNVSH TGVPLGEEYILVFSRTQNRL ILNEAELLLALAQEFQMKTV TVSLEDHTFADVVRLVSNAS M |
| Tissue Specificity | Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas. |
| Function | O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. |
| Protein Name | Protein O-Linked-Mannose Beta-1 -4-N-Acetylglucosaminyltransferase 2 Pomgnt2 Extracellular O-Linked N-Acetylglucosamine Transferase-Like Glycosyltransferase-Like Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5173105 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Protein O-Linked-Mannose Beta-1 -4-N-Acetylglucosaminyltransferase 2 antibody Anti-Pomgnt2 antibody Anti-Extracellular O-Linked N-Acetylglucosamine Transferase-Like antibody Anti-Glycosyltransferase-Like Domain-Containing Protein 2 antibody Anti-POMGNT2 antibody Anti-AGO61 antibody Anti-C3orf39 antibody Anti-EOGTL antibody Anti-GTDC2 antibody |
Information sourced from Uniprot.org