| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
POMC |
| Gene ID: |
5443 |
| Uniprot ID: |
COLI_HUMAN |
| Immunogen Region: |
200-267 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 200-267 of human POMC (NP_000930.1). |
| Immunogen Sequence: |
GAQADLEHSLLVAAEKKDEG PYRMEHFRWGSPPKDKRYGG FMTSEKSQTPLVTLFKNAII KNAYKKGE |
| Tissue Specificity | ACTH and MSH are produced by the pituitary gland. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated.reducing sugar is probably N-acetylgalactosamine. |
| Function | Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. |
| Protein Name | Pro-OpiomelanocortinPomcCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin GammaGamma-Msh - Potential Peptide - CorticotropinAdrenocorticotropic HormoneActh - Melanocyte-Stimulating Hormone AlphaAlpha-MshMelanotropin Alpha - Corticotropin-Like Intermediary PeptideClip - Lipotropin BetaBeta-Lph - Lipotropin GammaGamma-Lph - Melanocyte-Stimulating Hormone BetaBeta-MshMelanotropin Beta - Beta-Endorphin - Met-Enkephalin |
| Database Links | Reactome: R-HSA-111885Reactome: R-HSA-193048Reactome: R-HSA-194002Reactome: R-HSA-202040Reactome: R-HSA-209952Reactome: R-HSA-211976Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-5579031Reactome: R-HSA-6785807Reactome: R-HSA-9615017Reactome: R-HSA-9856649 |
| Cellular Localisation | SecretedMelanocyte-Stimulating Hormone Alpha And Beta-Endorphin Are Stored In Separate Granules In Hypothalamic Pomc NeuronsSuggesting That Secretion May Be Under The Control Of Different Regulatory Mechanisms |
| Alternative Antibody Names | Anti-Pro-Opiomelanocortin antibodyAnti-Pomc antibodyAnti-Corticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma antibodyAnti-Gamma-Msh - Potential Peptide - Corticotropin antibodyAnti-Adrenocorticotropic Hormone antibodyAnti-Acth - Melanocyte-Stimulating Hormone Alpha antibodyAnti-Alpha-Msh antibodyAnti-Melanotropin Alpha - Corticotropin-Like Intermediary Peptide antibodyAnti-Clip - Lipotropin Beta antibodyAnti-Beta-Lph - Lipotropin Gamma antibodyAnti-Gamma-Lph - Melanocyte-Stimulating Hormone Beta antibodyAnti-Beta-Msh antibodyAnti-Melanotropin Beta - Beta-Endorphin - Met-Enkephalin antibodyAnti-POMC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
