| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POLR3F (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3F |
| Gene ID: |
10621 |
| Uniprot ID: |
RPC6_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human POLR3F (NP_006457.2). |
| Immunogen Sequence: |
MAEVKVKVQPPDADPVEIEN RIIELCHQFPHGITDQVIQN EMPHIEAQQRAVAINRLLSM GQLDLLRSNTGLLYRIKDSQ NAGKMKGSDNQEKLVYQIIE DAGNKGIWSRDIRYKSNLPL TEINKILKNLESKKLIKAVK SVAASKKKVYMLYNLQPDRS VTGGAWYSDQDFESEFVEVL NQQCFKFLQSKAETARESKQ NPMIQRNSSFASSHEVWKYI |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA). |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc6Rna Polymerase Iii Subunit C6Dna-Directed Rna Polymerase Iii Subunit FRna Polymerase Iii 39 Kda SubunitRpc39 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc6 antibodyAnti-Rna Polymerase Iii Subunit C6 antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit F antibodyAnti-Rna Polymerase Iii 39 Kda Subunit antibodyAnti-Rpc39 antibodyAnti-POLR3F antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
