| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POLE3 (1-147) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLE3 |
| Gene ID: |
54107 |
| Uniprot ID: |
DPOE3_HUMAN |
| Immunogen Region: |
1-147 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human POLE3 (NP_059139.3). |
| Immunogen Sequence: |
MAERPEDLNLPNAVITRIIK EALPDGVNISKEARSAISRA ASVFVLYATSCANNFAMKGK RKTLNASDVLSAMEEMEFQR FVTPLKEALEAYRREQKGKK EASEQKKKDKDKKTDSEEQD KSRDEDNDEDEERLEEEEQN EEEEVDN |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. |
| Protein Name | Dna Polymerase Epsilon Subunit 3Arsenic-Transactivated ProteinAstpChromatin Accessibility Complex 17 Kda ProteinChrac-17Huchrac17Dna Polymerase Ii Subunit 3Dna Polymerase Epsilon Subunit P17 |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-5651801Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-68952Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Polymerase Epsilon Subunit 3 antibodyAnti-Arsenic-Transactivated Protein antibodyAnti-Astp antibodyAnti-Chromatin Accessibility Complex 17 Kda Protein antibodyAnti-Chrac-17 antibodyAnti-Huchrac17 antibodyAnti-Dna Polymerase Ii Subunit 3 antibodyAnti-Dna Polymerase Epsilon Subunit P17 antibodyAnti-POLE3 antibodyAnti-CHRAC17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
