Anti-PNPLA3 antibody (150-200) (STJ502570)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 150-200Β on human Patatin-like phospholipase domain-containing protein 3.
General Information
| Short Description | Rabbit polyclonal antibody anti-PNPLA3 (150-200) is suitable for use in Dot Blot, ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | DB/ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Bovine/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.68Β Β΅g/Β΅l |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20Β°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PNPLA3 |
| Gene ID | 80339 |
| Uniprot ID | PLPL3_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 150-200Β on human Patatin-like phospholipase domain-containing protein 3. |
| Immunogen Region | 150-200 |
Additional Info
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity. |
| Protein Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3Acylglycerol TransacylaseAdiponutrinAdpnCalcium-Independent Phospholipase A2-EpsilonIpla2-EpsilonLysophosphatidic Acid AcyltransferasePatatin-Like Phospholipase Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1482883 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinLipid Droplet |
| Alternative Antibody Names | Anti-1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 antibodyAnti-Acylglycerol Transacylase antibodyAnti-Adiponutrin antibodyAnti-Adpn antibodyAnti-Calcium-Independent Phospholipase A2-Epsilon antibodyAnti-Ipla2-Epsilon antibodyAnti-Lysophosphatidic Acid Acyltransferase antibodyAnti-Patatin-Like Phospholipase Domain-Containing Protein 3 antibodyAnti-PNPLA3 antibodyAnti-ADPN antibodyAnti-C22orf20 antibody |
Information sourced from Uniprot.org