Anti-PMCH antibody (112-161 aa) (STJ98825)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 112-161
General Information
| Short Description | Rabbit polyclonal anti-Pro-MCH (112-161 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PMCH |
| Gene ID | 5367 |
| Uniprot ID | MCH_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 112-161 |
| Immunogen Region | 112-161 aa |
| Specificity | The antibody detects endogenous PMCH |
Additional Info
| Post Translational Modifications | Differentially processed in the brain and in peripheral organs producing two neuropeptides.NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. |
| Protein Name | Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic AcidNgeNeuropeptide G-E - Neuropeptide-Glutamic Acid-IsoleucineNeiNeuropeptide E-I - Melanin-Concentrating HormoneMch |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic Acid antibodyAnti-Nge antibodyAnti-Neuropeptide G-E - Neuropeptide-Glutamic Acid-Isoleucine antibodyAnti-Nei antibodyAnti-Neuropeptide E-I - Melanin-Concentrating Hormone antibodyAnti-Mch antibodyAnti-PMCH antibodyAnti-MCH antibody |
Information sourced from Uniprot.org