Tissue Specificity | Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland. |
Post Translational Modifications | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet. |
Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
Protein Name | Perilipin-1Lipid Droplet-Associated Protein |
Database Links | Reactome: R-HSA-163560Reactome: R-HSA-381340Reactome: R-HSA-9031528 |
Cellular Localisation | Endoplasmic ReticulumLipid DropletLipid Droplet Surface-Associated |
Alternative Antibody Names | Anti-Perilipin-1 antibodyAnti-Lipid Droplet-Associated Protein antibodyAnti-PLIN1 antibodyAnti-PERI antibodyAnti-PLIN antibody |
Information sourced from Uniprot.org