Anti-PLEKHG5 antibody (STJ198362)

SKU:
STJ198362

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Pleckstrin homology domain-containing family G member 5 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLEKHG5
Gene ID: 57449
Uniprot ID: PKHG5_HUMAN
Specificity: This antibody detects endogenous levels of PLEKHG5 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the human PLEKHG5
Function Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts.
Protein Name Pleckstrin Homology Domain-Containing Family G Member 5
Ph Domain-Containing Family G Member 5
Guanine Nucleotide Exchange Factor 720
Gef720
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9696264
Reactome: R-HSA-9696273
Cellular Localisation Cytoplasm
Perinuclear Region
Cell Membrane
Cell Junction
Cell Projection
Lamellipodium
Predominantly Cytoplasmic
However When Endothelial Cells Are Stimulated With Lysophosphatidic Acid
Plekhg5 Is Found In Perinuclear Regions And At The Cell Membrane
Localizes At Cell-Cell Junctions In Quiescent Endothelial Cells
And Relocalizes To Cytoplasmic Vesicle And The Leading Edge Of Lamellipodia In Migrating Endothelial Cells
Alternative Antibody Names Anti-Pleckstrin Homology Domain-Containing Family G Member 5 antibody
Anti-Ph Domain-Containing Family G Member 5 antibody
Anti-Guanine Nucleotide Exchange Factor 720 antibody
Anti-Gef720 antibody
Anti-PLEKHG5 antibody
Anti-KIAA0720 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance