| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pleckstrin homology domain-containing family G member 5 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLEKHG5 |
| Gene ID: |
57449 |
| Uniprot ID: |
PKHG5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PLEKHG5 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from the human PLEKHG5 |
| Function | Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts. |
| Protein Name | Pleckstrin Homology Domain-Containing Family G Member 5Ph Domain-Containing Family G Member 5Guanine Nucleotide Exchange Factor 720Gef720 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneCell JunctionCell ProjectionLamellipodiumPredominantly CytoplasmicHowever When Endothelial Cells Are Stimulated With Lysophosphatidic AcidPlekhg5 Is Found In Perinuclear Regions And At The Cell MembraneLocalizes At Cell-Cell Junctions In Quiescent Endothelial CellsAnd Relocalizes To Cytoplasmic Vesicle And The Leading Edge Of Lamellipodia In Migrating Endothelial Cells |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family G Member 5 antibodyAnti-Ph Domain-Containing Family G Member 5 antibodyAnti-Guanine Nucleotide Exchange Factor 720 antibodyAnti-Gef720 antibodyAnti-PLEKHG5 antibodyAnti-KIAA0720 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
