| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLD4 (52-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLD4 |
| Gene ID: |
122618 |
| Uniprot ID: |
PLD4_HUMAN |
| Immunogen Region: |
52-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-200 of human PLD4 (NP_620145.2). |
| Immunogen Sequence: |
WQVPRPPTWGQVQPKDVPRS WEHGSSPAWEPLEAEARQQR DSCQLVLVESIPQDLPSAAG SPSAQPLGQAWLQLLDTAQE SVHVASYYWSLTGPDIGVND SSSQLGEALLQKLQQLLGRN ISLAVATSSPTLARTSTDLQ VLAARGAHV |
| Post Translational Modifications | Highly N-glycosylated. |
| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. |
| Protein Name | 5'-3' Exonuclease Pld4Choline Phosphatase 4Phosphatidylcholine-Hydrolyzing Phospholipase D4Phospholipase D Family Member 4Phospholipase D4Pld 4 |
| Database Links | Reactome: R-HSA-1483148Reactome: R-HSA-1855204Reactome: R-HSA-2029485 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneNucleusEarly EndosomeCytoplasmic VesiclePhagosomeActivation Of Microglia Induces Translocation Of Pld4 From The Nucleus To The Phagosomes |
| Alternative Antibody Names | Anti-5'-3' Exonuclease Pld4 antibodyAnti-Choline Phosphatase 4 antibodyAnti-Phosphatidylcholine-Hydrolyzing Phospholipase D4 antibodyAnti-Phospholipase D Family Member 4 antibodyAnti-Phospholipase D4 antibodyAnti-Pld 4 antibodyAnti-PLD4 antibodyAnti-C14orf175 antibodyAnti-UNQ2488 antibodyAnti-PRO5775 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
