| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1Pancreas-Enriched Phospholipase CPhosphoinositide Phospholipase C-Epsilon-1Phospholipase C-Epsilon-1Plc-Epsilon-1 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | CytoplasmCytosolCell MembraneGolgi Apparatus MembraneCell ProjectionLamellipodiumRecruited To Plasma Membrane By Activated Hras And Rap2Recruited To Perinuclear Membrane By Activated Rap1aIsoform 1 And Isoform 2 Associates With Golgi Membranes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1 antibodyAnti-Pancreas-Enriched Phospholipase C antibodyAnti-Phosphoinositide Phospholipase C-Epsilon-1 antibodyAnti-Phospholipase C-Epsilon-1 antibodyAnti-Plc-Epsilon-1 antibodyAnti-PLCE1 antibodyAnti-KIAA1516 antibodyAnti-PLCE antibodyAnti-PPLC antibody |
Information sourced from Uniprot.org
