• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-PLCE1 antibody (STJ191893)

SKU:
STJ191893

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase epsilon-1 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLCE1
Gene ID: 51196
Uniprot ID: PLCE1_HUMAN
Specificity: PLCE1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly.
Protein Name 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1
Pancreas-Enriched Phospholipase C
Phosphoinositide Phospholipase C-Epsilon-1
Phospholipase C-Epsilon-1
Plc-Epsilon-1
Database Links Reactome: R-HSA-1855204
Cellular Localisation Cytoplasm
Cytosol
Cell Membrane
Golgi Apparatus Membrane
Cell Projection
Lamellipodium
Recruited To Plasma Membrane By Activated Hras And Rap2
Recruited To Perinuclear Membrane By Activated Rap1a
Isoform 1 And Isoform 2 Associates With Golgi Membranes
Alternative Antibody Names Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1 antibody
Anti-Pancreas-Enriched Phospholipase C antibody
Anti-Phosphoinositide Phospholipase C-Epsilon-1 antibody
Anti-Phospholipase C-Epsilon-1 antibody
Anti-Plc-Epsilon-1 antibody
Anti-PLCE1 antibody
Anti-KIAA1516 antibody
Anti-PLCE antibody
Anti-PPLC antibody

Information sourced from Uniprot.org

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