| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCB1 |
| Gene ID: |
23236 |
| Uniprot ID: |
PLCB1_HUMAN |
| Immunogen Region: |
917-1216 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 917-1216 of human PLCB1 (NP_056007.1). |
| Immunogen Sequence: |
KSFVKLQKKHYKEMKDLVKR HHKKTTDLIKEHTTKYNEIQ NDYLRRRAALEKSAKKDSKK KSEPSSPDHGSSTIEQDLAA LDAEMTQKLIDLKDKQQQQL LNLRQEQYYSEKYQKREHIK LLIQKLTDVAEECQNNQLKK LKEICEKEKKELKKKMDKKR QEKITEAKSKDKSQMEEEKT EMIRSYIQEVVQYIKRLEEA QSKRQEKLVEKHKEIRQQIL DEKPKLQVELEQEYQDKFK |
| Post Translational Modifications | Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation. |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1Plc-154Phosphoinositide Phospholipase C-Beta-1Phospholipase C-IPlc-IPhospholipase C-Beta-1Plc-Beta-1 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657 |
| Cellular Localisation | Nucleus MembraneCytoplasmColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1 antibodyAnti-Plc-154 antibodyAnti-Phosphoinositide Phospholipase C-Beta-1 antibodyAnti-Phospholipase C-I antibodyAnti-Plc-I antibodyAnti-Phospholipase C-Beta-1 antibodyAnti-Plc-Beta-1 antibodyAnti-PLCB1 antibodyAnti-KIAA0581 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
