| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-PKA RI alpha for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R02-4R4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | PRKAR1A |
| Gene ID: | 5573 |
| Uniprot ID: | KAP0_HUMAN |
| Immunogen: | A synthesized peptide derived from human PRKAR1A |
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Post Translational Modifications | The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. |
| Protein Name | Camp-Dependent Protein Kinase Type I-Alpha Regulatory SubunitTissue-Specific Extinguisher 1Tse1 |
| Database Links | Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-180024Reactome: R-HSA-381676Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9700645Reactome: R-HSA-9725370Reactome: R-HSA-983231Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Type I-Alpha Regulatory Subunit antibodyAnti-Tissue-Specific Extinguisher 1 antibodyAnti-Tse1 antibodyAnti-PRKAR1A antibodyAnti-PKR1 antibodyAnti-PRKAR1 antibodyAnti-TSE1 antibody |
Information sourced from Uniprot.org
