| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PITX2 (20-70 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Pitx2 |
| Gene ID: |
18741 |
| Uniprot ID: |
PITX2_MOUSE |
| Immunogen Region: |
20-70 aa |
| Specificity: |
Specific for PITX2. |
| Immunogen: |
A synthetic peptide from aa region 20-70 of mouse Pituitary homeobox 2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform Ptx2c: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Brx1 HomeoproteinBicoid-Related Homeobox Protein 1Homeobox Protein Pitx2Orthodenticle-Like Homeobox 2Paired-Like Homeodomain Transcription Factor 2Solurshin |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Brx1 Homeoprotein antibodyAnti-Bicoid-Related Homeobox Protein 1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Orthodenticle-Like Homeobox 2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Solurshin antibodyAnti-Pitx2 antibodyAnti-Arp1 antibodyAnti-Brx1 antibodyAnti-Otlx2 antibodyAnti-Ptx2 antibodyAnti-Rgs antibodyAnti-Rieg antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
