| Post Translational Modifications | Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. |
| Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform Ptx2c: Involved in the establishment of left-right asymmetry in the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Brx1 HomeoproteinBicoid-Related Homeobox Protein 1Homeobox Protein Pitx2Orthodenticle-Like Homeobox 2Paired-Like Homeodomain Transcription Factor 2Solurshin |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Brx1 Homeoprotein antibodyAnti-Bicoid-Related Homeobox Protein 1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Orthodenticle-Like Homeobox 2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Solurshin antibodyAnti-Pitx2 antibodyAnti-Arp1 antibodyAnti-Brx1 antibodyAnti-Otlx2 antibodyAnti-Ptx2 antibodyAnti-Rgs antibodyAnti-Rieg antibody |
Information sourced from Uniprot.org
