| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IF |
| Reactivity: |
Human/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PIST/FIG/GOPC (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx. 55kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 50.5kDa according to NP_065132.1). Recommended concentration: 0.05-0.2µg/ml.IF: This product |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
GOPC |
| Gene ID: |
57120 |
| Uniprot ID: |
GOPC_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_065132.1; NP_001017408.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_065132.1; NP_001017408.1). |
| Immunogen Sequence: |
LDDLHTLYHKKSY |
| Function | Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. |
| Protein Name | Golgi-Associated Pdz And Coiled-Coil Motif-Containing ProteinCftr-Associated LigandFused In GlioblastomaPdz Protein Interacting Specifically With Tc10Pist |
| Database Links | Reactome: R-HSA-5627083Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneSynapsePostsynaptic DensityCell ProjectionDendriteEnriched In Synaptosomal And Postsynaptic Densities (Psd) FractionsExpressed In Cell Bodies And Dendrites Of Purkinje CellsLocalized At The Trans-Golgi Network (Tgn) Of Spermatids And The Medulla Of Round Spermatides |
| Alternative Antibody Names | Anti-Golgi-Associated Pdz And Coiled-Coil Motif-Containing Protein antibodyAnti-Cftr-Associated Ligand antibodyAnti-Fused In Glioblastoma antibodyAnti-Pdz Protein Interacting Specifically With Tc10 antibodyAnti-Pist antibodyAnti-GOPC antibodyAnti-CAL antibodyAnti-FIG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
