| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PI3R6 (590-640) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PIK3R6 |
| Gene ID: |
146850 |
| Uniprot ID: |
PI3R6_HUMAN |
| Immunogen Region: |
590-640 |
| Immunogen: |
Synthetic peptide taken within amino acid region 590-640 on human PhosphoInositide 3-kinase regulatory subunit 6. |
| Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis.signaling seems to involve RRAS. |
| Protein Name | Phosphoinositide 3-Kinase Regulatory Subunit 6Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KdaP84 Pi3k Adapter ProteinP84 PikapP87 Pi3k Adapter ProteinP87pikap |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1660499Reactome: R-HSA-392451 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinTranslocated To The Plasma Membrane In A Ras-Dependent Manner |
| Alternative Antibody Names | Anti-Phosphoinositide 3-Kinase Regulatory Subunit 6 antibodyAnti-Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda antibodyAnti-P84 Pi3k Adapter Protein antibodyAnti-P84 Pikap antibodyAnti-P87 Pi3k Adapter Protein antibodyAnti-P87pikap antibodyAnti-PIK3R6 antibodyAnti-C17orf38 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
