| Short Description : | Rabbit polyclonal PI3 (23-117) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PI3 |
| Gene ID: | 5266 |
| Uniprot ID: | ELAF_HUMAN |
| Immunogen Region: | 23-117 |
| Immunogen Sequence: | AVTGVPVKGQDTVKGRVPFN GQDPVKGQVSVKGQDKVKAQ EPVKGPVSTKPGSCPIILIR CAMLNPPNRCLKDTDCPGIK KCCEGSCGMACFVPQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-117 of human PI3 (NP_002629.1). |
| Function | Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1). |
| Protein Name | ElafinElastase-Specific InhibitorEsiPeptidase Inhibitor 3Pi-3Protease Inhibitor Wap3Skin-Derived AntileukoproteinaseSkalpWap Four-Disulfide Core Domain Protein 14 |
| Database Links | Reactome: R-HSA-6803157Reactome: R-HSA-6809371 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Elafin antibodyAnti-Elastase-Specific Inhibitor antibodyAnti-Esi antibodyAnti-Peptidase Inhibitor 3 antibodyAnti-Pi-3 antibodyAnti-Protease Inhibitor Wap3 antibodyAnti-Skin-Derived Antileukoproteinase antibodyAnti-Skalp antibodyAnti-Wap Four-Disulfide Core Domain Protein 14 antibodyAnti-PI3 antibodyAnti-WAP3 antibodyAnti-WFDC14 antibody |
Information sourced from Uniprot.org
