| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-Phosphodiesterase 4B (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000. WB: Approx 85kDa band observed in Mouse Brain lysates (calculated MW of 83.3kDa according to Human NP_002591.2 and 82.1kDa according to Mouse NP_062814.2). In transfected HEK293 transiently |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PDE4B |
| Gene ID: | 5142 |
| Uniprot ID: | PDE4B_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_002591.2; NP_001032418.1; NP_001032416.1; NP_001032417.1 |
| Specificity: | This antibody is expected to recognise all reported isoforms (NP_002591.2, NP_001032418.1, NP_001032416.1 and NP_001032417.1). |
| Immunogen Sequence: | DIDIATEDKSPVDT |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
| Protein Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4b Dpde4 Pde32 Camp-Specific Phosphodiesterase 4b |
| Database Links | Reactome: R-HSA-180024 Q07343-3 |
| Cellular Localisation | Isoform Pde4b5: Cytoplasm Cell Membrane |
| Alternative Antibody Names | Anti-3' -5'-Cyclic-Amp Phosphodiesterase 4b antibody Anti-Dpde4 antibody Anti-Pde32 antibody Anti-Camp-Specific Phosphodiesterase 4b antibody Anti-PDE4B antibody Anti-DPDE4 antibody |
Information sourced from Uniprot.org
