| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Talin-1-Ser425 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLN1 |
| Gene ID: | 7094 |
| Uniprot ID: | TLN1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human Mouse Rat Talin (phospho-Ser425) |
| Immunogen: | Synthesized phosho peptide around human Talin (Ser425) |
| Function | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. |
| Protein Name | Talin-1 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-381038 Reactome: R-HSA-399955 Reactome: R-HSA-445355 Reactome: R-HSA-5674135 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytoskeleton Cell Surface Cell Junction Focal Adhesion Colocalizes With Layn At The Membrane Ruffles Localized Preferentially In Focal Adhesions Than Fibrillar Adhesions |
| Alternative Antibody Names | Anti-Talin-1 antibody Anti-TLN1 antibody Anti-KIAA1027 antibody Anti-TLN antibody |
Information sourced from Uniprot.org