| Post Translational Modifications | Phosphorylated at Thr-9 following detection of ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) by ALPK1. Phosphorylation at Thr-9 by ALPK1 leads to the formation of an intermolecular binding between the FHA domain and phosphorylated Thr-9, promoting TIFA oligomerization and TIFA-mediated NF-kappa-B activation. |
| Function | Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling. |
| Protein Name | Traf-Interacting Protein With Fha Domain-Containing Protein APutative Mapk-Activating Protein Pm14Putative Nf-Kappa-B-Activating Protein 20Traf2-Binding Protein |
| Database Links | Reactome: R-HSA-445989Reactome: R-HSA-9645460 |
| Cellular Localisation | CytoplasmColocalizes With Lysosomal Marker Lamp2 Following Homooligomerization And Subsequent Activation |
| Alternative Antibody Names | Anti-Traf-Interacting Protein With Fha Domain-Containing Protein A antibodyAnti-Putative Mapk-Activating Protein Pm14 antibodyAnti-Putative Nf-Kappa-B-Activating Protein 20 antibodyAnti-Traf2-Binding Protein antibodyAnti-TIFA antibodyAnti-T2BP antibody |
Information sourced from Uniprot.org
