Anti-Phospho-TAL1-Ser122 antibody (96-145 aa) (STJ90638)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TAL-1 around the phosphorylation site of Ser122 at the amino acid range 96-145
General Information
| Short Description | Rabbit polyclonal anti-Phospho-T-cell acute lymphocytic leukemia protein 1-Ser122 (96-145 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAL1 |
| Gene ID | 6886 |
| Uniprot ID | TAL1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TAL-1 around the phosphorylation site of Ser122 at the amino acid range 96-145 |
| Immunogen Region | 96-145 aa |
| Specificity | Phospho-TAL1 (S122) Polyclonal Antibody detects endogenous levels of TAL1 protein only when phosphorylated at S122. |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated.subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells. |
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. |
| Protein Name | T-Cell Acute Lymphocytic Leukemia Protein 1Tal-1Class A Basic Helix-Loop-Helix Protein 17Bhlha17Stem Cell ProteinT-Cell Leukemia/Lymphoma Protein 5 |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9616222 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Cell Acute Lymphocytic Leukemia Protein 1 antibodyAnti-Tal-1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 17 antibodyAnti-Bhlha17 antibodyAnti-Stem Cell Protein antibodyAnti-T-Cell Leukemia/Lymphoma Protein 5 antibodyAnti-TAL1 antibodyAnti-BHLHA17 antibodyAnti-SCL antibodyAnti-TCL5 antibody |
Information sourced from Uniprot.org