| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Synapsin-1-Ser9 (3-52 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYN1 |
| Gene ID: | 6853 |
| Uniprot ID: | SYN1_HUMAN |
| Immunogen Region: | 3-52 aa |
| Specificity: | Phospho-Synapsin I (S9) Polyclonal Antibody detects endogenous levels of Synapsin I protein only when phosphorylated at S9. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Synapsin around the phosphorylation site of Ser9 at the amino acid range 3-52 |
| Function | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. |
| Protein Name | Synapsin-1 Brain Protein 4.1 Synapsin I |
| Database Links | Reactome: R-HSA-181429 Reactome: R-HSA-212676 Reactome: R-HSA-9662360 |
| Cellular Localisation | Synapse Golgi Apparatus Presynapse Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Dissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential Firing In A Step That Precedes Fusion Of Vesicles With The Plasma Membrane Reclusters To Presynapses After The Cessation Of Synaptic Activity |
| Alternative Antibody Names | Anti-Synapsin-1 antibody Anti-Brain Protein 4.1 antibody Anti-Synapsin I antibody Anti-SYN1 antibody |
Information sourced from Uniprot.org