Western blot of rat striatal lysate showing specific immunolabeling of the ~55 kDa glycosylated form of the DAT protein phosphorylated at Thr53 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).

Anti-Phospho-SLC6A3-Thr53 antibody (STJA0003618)

SKU:
STJA0003618-100
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Dopamine Transporter-Thr53 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Slc6a3
Gene ID: 24898
Uniprot ID: SC6A3_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr53 conjugated to KLH.
Tissue Specificity Brain. Expressed in the substantia nigra and ventral tegmental area, regions that contain dopaminergic cell bodies.
Function Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Protein Name Sodium-Dependent Dopamine Transporter
Da Transporter
Dat
Solute Carrier Family 6 Member 3
Database Links Reactome: R-RNO-379401
Reactome: -RNO-442660
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Neuron Projection
Axon
Localizes To Neurite Tips In Neuronal Cells
Colocalizes With Septin4 At Axon Terminals
Especially At The Varicosities
Alternative Antibody Names Anti-Sodium-Dependent Dopamine Transporter antibody
Anti-Da Transporter antibody
Anti-Dat antibody
Anti-Solute Carrier Family 6 Member 3 antibody
Anti-Slc6a3 antibody

Information sourced from Uniprot.org

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