• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).
  • Western Blot analysis of various, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-Phospho-PRKG2-Ser126 antibody (92-141 aa) (STJ91216)

SKU:
STJ91216

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-cGMP-dependent protein kinase 2-Ser126 (92-141 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRKG2
Gene ID: 5593
Uniprot ID: KGP2_HUMAN
Immunogen Region: 92-141 aa
Specificity: Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126.
Immunogen: The antiserum was produced against synthesized peptide derived from the human PKG2 around the phosphorylation site of Ser126 at the amino acid range 92-141
Post Translational Modifications Myristoylation mediates membrane localization.
Function Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation.
Protein Name Cgmp-Dependent Protein Kinase 2
Cgk 2
Cgk2
Cgmp-Dependent Protein Kinase Ii
Cgkii
Database Links Reactome: R-HSA-1474151
Reactome: R-HSA-4086398
Reactome: R-HSA-418457
Reactome: R-HSA-9648002
Cellular Localisation Apical Cell Membrane
Lipid-Anchor
Alternative Antibody Names Anti-Cgmp-Dependent Protein Kinase 2 antibody
Anti-Cgk 2 antibody
Anti-Cgk2 antibody
Anti-Cgmp-Dependent Protein Kinase Ii antibody
Anti-Cgkii antibody
Anti-PRKG2 antibody
Anti-PRKGR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance