| Short Description : | Rabbit polyclonal anti-Phospho-Astrocytic phosphoprotein PEA-15-Ser116 (81-130 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PEA15 |
| Gene ID: | 8682 |
| Uniprot ID: | PEA15_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PEA-15 around the phosphorylation site of Ser116 at the amino acid range 81-130 |
| Immunogen Region: | 81-130 aa |
| Specificity: | Phospho-PEA-15 (S116) Polyclonal Antibody detects endogenous levels of PEA-15 protein only when phosphorylated at S116. |
| Post Translational Modifications | Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. |
| Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
| Protein Name | Astrocytic Phosphoprotein Pea-1515 Kda Phosphoprotein Enriched In AstrocytesPhosphoprotein Enriched In DiabetesPed |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmAssociated With Microtubules |
| Alternative Antibody Names | Anti-Astrocytic Phosphoprotein Pea-15 antibodyAnti-15 Kda Phosphoprotein Enriched In Astrocytes antibodyAnti-Phosphoprotein Enriched In Diabetes antibodyAnti-Ped antibodyAnti-PEA15 antibody |
Information sourced from Uniprot.org
