| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-PAS domain-containing serine/threonine-protein kinase-Thr1165 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PASK |
| Gene ID: |
23178 |
| Uniprot ID: |
PASK_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PASK (Phospho-Thr1165) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PASK (Phospho-Thr1165) |
| Tissue Specificity | Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level). |
| Post Translational Modifications | Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids. |
| Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells.however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. |
| Protein Name | Pas Domain-Containing Serine/Threonine-Protein KinasePas-KinasePaskinHpask |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Nucleus Of Testis Germ Cells And In The Midpiece Of Sperm Tails |
| Alternative Antibody Names | Anti-Pas Domain-Containing Serine/Threonine-Protein Kinase antibodyAnti-Pas-Kinase antibodyAnti-Paskin antibodyAnti-Hpask antibodyAnti-PASK antibodyAnti-KIAA0135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
