| Tissue Specificity | Isoform Alpha-1: Expressed in the liver and brain (at protein level). Isoform Alpha-2: Expressed in the liver and brain (at protein level). Isoform Beta: Expressed in the liver, muscle, testes, lung, kidney, spleen, heart and brain (at protein level). |
| Post Translational Modifications | Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 5Map Kinase Kinase 5Mapkk 5Mapk/Erk Kinase 5Mek 5 |
| Cellular Localisation | Isoform Beta: CytoplasmCytosolIsoform Alpha-1: MembraneThe Alternatively Spliced Exon In Alpha Isoform Resemble Conserved Sequences That Mediate Interactions With The CytoskeletonThereby Explaining The Differential LocalizationIsoform Alpha-2: Membrane |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 antibodyAnti-Map Kinase Kinase 5 antibodyAnti-Mapkk 5 antibodyAnti-Mapk/Erk Kinase 5 antibodyAnti-Mek 5 antibodyAnti-Map2k5 antibodyAnti-Mek5 antibodyAnti-Mkk5 antibodyAnti-Prkmk5 antibody |
Information sourced from Uniprot.org
