• Western Blot analysis of HeLa cell, 2, LPS 100ng/mL 30min treated, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-Phospho-KIZ-Thr379 antibody (STJA0009998)

SKU:
STJA0009998

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Centrosomal protein kizuna-Thr379 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KIZ
Gene ID: 55857
Uniprot ID: KIZ_HUMAN
Specificity: This antibody detects endogenous levels of Kizuna (Phospho-Thr379) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Kizuna (Phospho-Thr379)
Post Translational Modifications Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.
Function Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Protein Name Centrosomal Protein Kizuna
Polo-Like Kinase 1 Substrate 1
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cilium Basal Body
Localizes To Centrosomes Throughout The Cell Cycle
After Centrosome Duplication
It Usually Remains Associated Only With The Mother Centrosome
Containing The Older Mature Centriole And Particles Surrounding It
During Prophase
Additional Particles Accumulate Around Both Separating Centrosomes
Does Not Accumulate At The Microtubule Minus Ends
But Instead Localizes To The Centrosomes And Centrosome-Surrounding Area In A Microtubule-Independent And Dependent Manner
Respectively
Alternative Antibody Names Anti-Centrosomal Protein Kizuna antibody
Anti-Polo-Like Kinase 1 Substrate 1 antibody
Anti-KIZ antibody
Anti-C20orf19 antibody
Anti-NCRNA00153 antibody
Anti-PLK1S1 antibody
Anti-HT013 antibody

Information sourced from Uniprot.org

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