• Immunostaining of Chinese Hamster Overy (CHO) cells stably transfected with KV3. 1b gene with the phospho-Ser503 Kv3. 1 subunit antibody (STJA0003752, green, 1:400). The image on the right shows cells that have been treated with the protein kinase C activator PMA (500nM) while the control cells are on the left.

Anti-Phospho-KCNC1-Ser503 antibody (STJA0003752)

SKU:
STJA0003752-100

£442.50
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Host: Rabbit
Applications: WB/IHC/ICC
Reactivity: Hamster/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Kv3.1-Ser503 is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC 1:400-1:1000
ICC 1:400
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Kcnc1
Gene ID: 25327
Uniprot ID: KCNC1_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH.
Tissue Specificity Expressed in brain. Expressed in globus pallidal neurons of the basal ganglia (at protein level). Detected on Purkinje cells in the cerebellum molecular layer (at protein level).
Post Translational Modifications N-glycosylated.contains sialylated glycans.
Function Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Protein Name Potassium Voltage-Gated Channel Subfamily C Member 1
Ngk2
Raw2
Voltage-Gated Potassium Channel Subunit Kv3.1
Voltage-Gated Potassium Channel Subunit Kv4
Database Links Reactome: R-RNO-1296072
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Axon
Presynaptic Cell Membrane
Localizes In Parallel Fiber Membranes
Distributed On The Perisynaptic And Extrasynaptic Membranes Away From The Active Zones
Alternative Antibody Names Anti-Potassium Voltage-Gated Channel Subfamily C Member 1 antibody
Anti-Ngk2 antibody
Anti-Raw2 antibody
Anti-Voltage-Gated Potassium Channel Subunit Kv3.1 antibody
Anti-Voltage-Gated Potassium Channel Subunit Kv4 antibody
Anti-Kcnc1 antibody

Information sourced from Uniprot.org

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