| Tissue Specificity | Expressed in brain. Expressed in globus pallidal neurons of the basal ganglia (at protein level). Detected on Purkinje cells in the cerebellum molecular layer (at protein level). |
| Post Translational Modifications | N-glycosylated.contains sialylated glycans. |
| Function | Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (Probable). The mechanism is time-dependent and inactivation is slow. Plays an important role in the rapid repolarization of fast-firing brain neurons. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc1Ngk2Potassium Voltage-Gated Channel Subfamily C Member 1Raw2Voltage-Gated Potassium Channel Subunit Kv3.1Voltage-Gated Potassium Channel Subunit Kv4 |
| Database Links | Reactome: R-RNO-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonPresynaptic Cell MembraneLocalizes In Parallel Fiber MembranesDistributed On The Perisynaptic And Extrasynaptic Membranes Away From The Active Zones |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc1 antibodyAnti-Ngk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 1 antibodyAnti-Raw2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4 antibodyAnti-Kcnc1 antibody |
Information sourced from Uniprot.org
