| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Hematopoietic lineage cell-specific protein-Tyr397 (366-415 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HCLS1 |
| Gene ID: | 3059 |
| Uniprot ID: | HCLS1_HUMAN |
| Immunogen Region: | 366-415 aa |
| Specificity: | Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HS1 around the phosphorylation site of Tyr397 at the amino acid range 366-415 |
| Post Translational Modifications | Phosphorylated by FES. Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. |
| Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| Protein Name | Hematopoietic Lineage Cell-Specific ProteinHematopoietic Cell-Specific Lyn Substrate 1Lckbp1P75 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Hematopoietic Lineage Cell-Specific Protein antibodyAnti-Hematopoietic Cell-Specific Lyn Substrate 1 antibodyAnti-Lckbp1 antibodyAnti-P75 antibodyAnti-HCLS1 antibodyAnti-HS1 antibody |
Information sourced from Uniprot.org