Anti-Phospho-GYS1-S641 antibody (STJ11101015)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Phospho-GYS1-S641 antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GYS1 |
| Gene ID | 2997 |
| Uniprot ID | GYS1_HUMAN |
| Immunogen Sequence | PASVP |
| Specificity | A synthetic phosphorylated peptide around S641 of human Glycogen synthase 1 (GYS1) (NP_002094.2). |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle and most other cell types where glycogen is present. |
| Post Translational Modifications | Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Phosphorylated at Ser-641 by PASK, leading to inactivation.phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. |
| Function | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name | Glycogen Starch Synthase - MuscleGlycogen Synthase 1 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3785653Reactome: R-HSA-3814836Reactome: R-HSA-3828062 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Glycogen Starch Synthase - Muscle antibodyAnti-Glycogen Synthase 1 antibodyAnti-GYS1 antibodyAnti-GYS antibody |
Information sourced from Uniprot.org