| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Beta-adrenergic receptor kinase 1-Ser29 (14-63 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRK2 |
| Gene ID: | 156 |
| Uniprot ID: | ARBK1_HUMAN |
| Immunogen Region: | 14-63 aa |
| Specificity: | Phospho-GRK 2 (S29) Polyclonal Antibody detects endogenous levels of GRK 2 protein only when phosphorylated at S29. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GRK2 around the phosphorylation site of Ser29 at the amino acid range 14-63 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1 Beta-Ark-1 G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933 Reactome: R-HSA-416476 Reactome: R-HSA-418555 Reactome: R-HSA-5635838 Reactome: R-HSA-8856825 |
| Cellular Localisation | Cytoplasm Cell Membrane Postsynapse Presynapse |
| Alternative Antibody Names | Anti-Beta-Adrenergic Receptor Kinase 1 antibody Anti-Beta-Ark-1 antibody Anti-G-Protein Coupled Receptor Kinase 2 antibody Anti-GRK2 antibody Anti-ADRBK1 antibody Anti-BARK antibody Anti-BARK1 antibody |
Information sourced from Uniprot.org