• Western blot analysis of lysates from HepG2 cells treated with Forskolin 40nM 30', using GluR4 (Phospho-Ser862) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunohistochemistry analysis of paraffin-embedded human brain, using GluR4 (Phospho-Ser862) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-GRIA4-Ser862 antibody (828-877 aa) (STJ90900)

SKU:
STJ90900

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Glutamate receptor 4-Ser862 (828-877 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRIA4
Gene ID: 2893
Uniprot ID: GRIA4_HUMAN
Immunogen Region: 828-877 aa
Specificity: Phospho-GluR4 (S862) Polyclonal Antibody detects endogenous levels of GluR4 protein only when phosphorylated at S862.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GluR4 around the phosphorylation site of Ser862 at the amino acid range 828-877
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Protein Name Glutamate Receptor 4
Glur-4
Glur4
Ampa-Selective Glutamate Receptor 4
Glur-D
Glutamate Receptor Ionotropic - Ampa 4
Glua4
Database Links Reactome: R-HSA-399710
Reactome: R-HSA-399719
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-8849932
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Cell Projection
Dendrite
Interaction With Cnih2
Cnih3 And Prkcg Promotes Cell Surface Expression
Alternative Antibody Names Anti-Glutamate Receptor 4 antibody
Anti-Glur-4 antibody
Anti-Glur4 antibody
Anti-Ampa-Selective Glutamate Receptor 4 antibody
Anti-Glur-D antibody
Anti-Glutamate Receptor Ionotropic - Ampa 4 antibody
Anti-Glua4 antibody
Anti-GRIA4 antibody
Anti-GLUR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance