| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat/Canine/Chicken |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-GluR1-Ser831 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Gria1 |
| Gene ID: |
50592 |
| Uniprot ID: |
GRIA1_RAT |
| Immunogen: |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser831 conjugated to KLH. |
| Tissue Specificity | Detected in cerebellum (at protein level). |
| Post Translational Modifications | Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation. Palmitoylated. Depalmitoylated by CPT1C and upon L-glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-603, which leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. |
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex. Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+). |
| Protein Name | Glutamate Receptor 1Glur-1Ampa-Selective Glutamate Receptor 1Glur-AGlur-K1Glutamate Receptor Ionotropic - Ampa 1 |
| Database Links | Reactome: R-RNO-204005Reactome: -RNO-399710Reactome: -RNO-399719Reactome: -RNO-416993Reactome: -RNO-438066Reactome: -RNO-5694530Reactome: -RNO-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembranePostsynaptic Cell MembranePostsynaptic Density MembraneCell ProjectionDendriteDendritic SpineEarly Endosome MembraneRecycling Endosome MembranePresynapseSynapseInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionColocalizes With Pdlim4 In Early EndosomesDisplays A Somatodendritic Localization And Is Excluded From Axons In NeuronsLocalized To Cone Photoreceptor Pedicles |
| Alternative Antibody Names | Anti-Glutamate Receptor 1 antibodyAnti-Glur-1 antibodyAnti-Ampa-Selective Glutamate Receptor 1 antibodyAnti-Glur-A antibodyAnti-Glur-K1 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 1 antibodyAnti-Gria1 antibodyAnti-GluA1 antibodyAnti-Glur1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
