| Short Description : | Rabbit polyclonal Phospho-GAB1-Y659 antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GAB1 |
| Gene ID: | 2549 |
| Uniprot ID: | GAB1_HUMAN |
| Immunogen Sequence: | VDYVV |
| Specificity: | A synthetic phosphorylated peptide around Y659 of human GAB1 (NP_002030.2). |
| Post Translational Modifications | Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. |
| Function | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. |
| Protein Name | Grb2-Associated-Binding Protein 1Grb2-Associated Binder 1Growth Factor Receptor Bound Protein 2-Associated Protein 1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1236382Reactome: R-HSA-1257604Reactome: R-HSA-180292Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5637810Reactome: R-HSA-5654689Reactome: R-HSA-5654695Reactome: R-HSA-5654710Reactome: R-HSA-5654720Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-6811558Reactome: R-HSA-8851907Reactome: R-HSA-8853659Reactome: R-HSA-8865999Reactome: R-HSA-8875555Reactome: R-HSA-8875656Reactome: R-HSA-9027276Reactome: R-HSA-9028335Reactome: R-HSA-9664565Reactome: R-HSA-9665348 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 1 antibodyAnti-Grb2-Associated Binder 1 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 1 antibodyAnti-GAB1 antibody |
Information sourced from Uniprot.org
