| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Forkhead box protein M1-Thr600 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FOXM1 |
| Gene ID: |
2305 |
| Uniprot ID: |
FOXM1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Human FoxM1 (phospho-Thr600) |
| Immunogen: |
Synthesized phosho peptide around human FoxM1 (Thr600) |
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2. |
| Protein Name | Forkhead Box Protein M1Forkhead-Related Protein Fkhl16Hepatocyte Nuclear Factor 3 Forkhead Homolog 11Hfh-11Hnf-3/Fork-Head Homolog 11M-Phase Phosphoprotein 2Mpm-2 Reactive Phosphoprotein 2Transcription Factor TridentWinged-Helix Factor From Ins-1 Cells |
| Database Links | Reactome: R-HSA-156711Reactome: R-HSA-69273 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Forkhead Box Protein M1 antibodyAnti-Forkhead-Related Protein Fkhl16 antibodyAnti-Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 antibodyAnti-Hfh-11 antibodyAnti-Hnf-3/Fork-Head Homolog 11 antibodyAnti-M-Phase Phosphoprotein 2 antibodyAnti-Mpm-2 Reactive Phosphoprotein 2 antibodyAnti-Transcription Factor Trident antibodyAnti-Winged-Helix Factor From Ins-1 Cells antibodyAnti-FOXM1 antibodyAnti-FKHL16 antibodyAnti-HFH11 antibodyAnti-MPP2 antibodyAnti-WIN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
