| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FADD |
| Gene ID: | 8772 |
| Uniprot ID: | FADD_HUMAN |
| Immunogen Sequence: | AMSPM |
| Specificity: | A synthetic phosphorylated peptide around S194 of human FADD (NP_003815.1). |
| Tissue Specificity | Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. |
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. |
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinGrowth-Inhibiting Gene 3 ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-2562578Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5675482Reactome: R-HSA-69416Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-9013957Reactome: R-HSA-933543Reactome: R-HSA-9693928 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Fas-Associated Death Domain Protein antibodyAnti-Fas-Associating Death Domain-Containing Protein antibodyAnti-Growth-Inhibiting Gene 3 Protein antibodyAnti-Mediator Of Receptor Induced Toxicity antibodyAnti-FADD antibodyAnti-MORT1 antibodyAnti-GIG3 antibody |
Information sourced from Uniprot.org
